Carnitine: Special Forms for healthy nerve & cognitive function, male reproduction, cardiovascular health, and exercise tolerance.

Article by Don Goldberg

ArginoCarnTM, USP (brand of Acetyl-L-Carnitine Arginate Dihydrochloride, USP)

Support for healthy neuron and cognitive function; may promote healthy male reproductive function

Precursors of carnitine and acetyl-l-carnitine,
including the animoacid arginine, may help to
enhance the metabolic activities of these
compounds. An acetyl-l-carnitine arginine complex
supported healthy neuron viability in a cellular in
vitro experiment. in the same study, the
acetyl-l-carnitine arginine complex was able to help
maintain calcium homeostasis in nervous system
cells stimulated with glutamate, preserving healthy
cerebellar cell function. In a separate study,
acetyl-l-carnitine arginate demonstrated potential
support for maintaining healthy central nervous
system function by promoting healthy neurite
function. Neurites are the hair like projections of
neurons, or nervous system cells, responsible for
proper signal transmission. the acetyl group from
acetyl-l-carnitine (ALC) is also responsible for
production of acetylcholine, an important
neurotransmitter for optimal mental functioning.
The efficacy of long-term acetyl-l-carnitine
supplementation was investigated in a double-blind,
placebo-controlled, randomized trial, in which
acetyl-l-carnitine demonstrated the ability to slow
negative cognitive changes and supported memory
and attention. A randomized double-blind study and
a multicentre trial suggested that acetyl-l-carnitine
supplementation provided statistically significant
support for mental function, including memory and
attention, and behavioural and emotional support.

Acetyl-l-carnitine and arginine also play roles in healthy male reproductive function.

Acetyl-l-carnitine is present in human sperm and
seminal fluid and plays an important part in energy
metabolism, which may support healthy sperm
motility and spermatogenesis, or sperm production.
As a nitric oxide precursor, l-arginine may support
healthy sexual function in men with low urinary
nitric oxide values. Furthermore, some but not all
research involving l-arginine supplementation for
sperm motility is tested; otherwise healthy males
have produced healthy results.

Summary: ArginoCarnTM, USP is an innovative Acetyl-L-Carnitine Arginate complex providing important protection for healthy neuron function and cognitive health and could offer a potential for healthy support for male reproductive health.
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GlycoCarnTM, USP (brand of Glycine Propionyl-L-Carnitine Hydrochloride, USP)

Enhanced support for healthy cardiovascular performance and exercise tolerance

Propionyl-l-carnitine (PLC) as derived from
GlycoCarnTM, USP is a carnitine derivative naturally
produced in the body. It has been specifically
investigated for its role in cardiovascular metabolic
function, peripheral artery health, and exercise
capacity. It has been noted for promoting energy
metabolism and oxygen availability in muscles with
a high workload. Studies suggest that PLC supports
healthy myocardial contractility, heart muscle
meta-bolism, heart cell membrane stability, skeletal
muscle metabolism, Krebs cycle activity and lactate
modulation. A 6-month randomized, double-blind
study involving 50 subjects suggested that PLC
supplementation supported maximum exercise
capacity and promoted vascular health. In a
controlled double-blind trial with 60 participants,
PLC promoted exercise tolerance an