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Page 11 To place an order, go to www.willner.com or call (800) 633-1106 Since 1911 • Willner Chemists: The Nutritional Supplement Professionals PQQ and Ubiquinol: Potent Free Radical Scavengers and Dual Support for Mitochondria * PQQ, pyrroloquinoline quinone, and ubiquinol are compounds found in most cells of the human body. They work independently throughout the body to exert their health promoting functions.* PQQ is known to be involved in a multitude of biological processes. It is a potent free radical scavenger that also activates several cell signaling pathways associated with the cellular production of new mitochondria and the regulation of cellular energy metabolism.* PQQ has been shown to counteract toxin- and free radical-induced neurodegeneration and to enhance the synthesis of nerve growth factor.* These biological properties are especially important for cells with high energy demands, such as those found in the heart and brain.* Supplementing the diet with PQQ may therefore support heart health and promote normal cognitive function.* Ubiquinol is a form of coenzyme Q10 (CoQ10). In a clinical study, when administered to healthy adult volunteers at a single dose of 150 mg, ubiquinol results in twice the total plasma CoQ10 concentrations as from the same dose of ubiquinone (solubilized/suspended in oil, softgels). At the cellular level, CoQ10 is critical for the synthesis of ATP in mitochondria, as 96% of all aerobically produced energy in cells involves CoQ10.* Organs like the heart and skeletal muscle require consistent and robust ATP production; the presence of CoQ10 is therefore especially important for these organs.* CoQ10 is also known to be a potent free radical scavenger.*In laboratory experiments, CoQ10 in the form of ubiquinol modulates lipid peroxidation and helps to regenerate vitamin E and vitamin C.* In experiments aiming at exploring the effect of PQQ and CoQ10, either alone or in combination, on the learning ability and memory function of laboratory animals, the combination of both compounds resulted in no significant improvement in learning ability when compared with the supplementation of PQQ alone.* However, when the tested animals were subjected to an experimental oxidative stress (hyperbaric oxygen), animals in the PQQ- CoQ10 group fared better in terms of maintenance of memory function than in the respective single supplementations groups.* Researchers who performed these experiments concluded that a synergy between PQQ and CoQ10 exists in the brain, and that it is most likely due to their powerful free radical scavenging properties.* While these are very preliminary results, they cast light on the complementarity of PQQ and CoQ10 for brain health.* And because ubiquinol is able to better raise CoQ10 blood levels than ubiquinone, it makes sense to supplement the diet with PQQ and ubiquinol to get the best form for each compound. Whether you are taking PQQ and ubiquinol for their free radical scavenging and/or mitochondrial support properties, Protocol For Life Balance offers two PQQ (20 & 40 mg) and two ubiquinol (100 & 200 mg) products. Proposing different forms and dosages of each compound allows you to optimally enrich your diet with PQQ and ubiquinol either alone and in combination. In this way, you can then tailor the dose and form to your specific needs, which you cannot achieve with fixed combination products. Note: Protocol For Life Balance scientific and R&D teams do not perform experiments on laboratory animals. Our in-house laboratories to not hold any animals. However, to support our label claims we perform extensive literature research and rely on data from articles published in peer review journals that sometimes describe experiments using laboratory animals. The use of laboratory animals, while contested, remains an integral part of the scientific method. P QQ, Pyrroloquinoline quinone, and Ubiquinol are compounds found in most cells of the human body. They work independently throughout the body to exert their health promoting functions.* *Note: Information in this article is provided for informational purposes only. Any and all information is not intended as a substitute for the advice provided by your physician or other healthcare provider. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. PQQ has been shown to counteract toxin and free radical- induced neurodegeneration and to enhance the synthesis of nerve growth factor.* The pharmacists and nutritionists at Willner Chemists will be happy to assist you in determining which supplements are most appropriate for your needs. By Celine Torres-Moon, Science Writer, Protocol For Life Balance