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G inkgo biloba and Alzheimer's. Doctors don't know what causes Alzheimer's disease (AD), but Chinese medicine has used ginkgo biloba to treat cognitive disorders for centuries. In this study, doctors identified six proteins associated with Alzheimer's disease that may have protective and preventive effects when networked with compounds in ginkgo biloba. In a computer generated mathematics and statistical model, doctors integrated these proteins with compounds in ginkgo biloba and found several beneficial effects, including ginkgo biloba dissolving a particular protein called "tau," before it could form into the type of plaque found in Alzheimer's disease. The results suggest a possible Alzheimer's disease therapy using ginkgo biloba. Reference: Nutrients; May 2018, Published Online Quercetin and senolytic drugs. As normal cells age, they stop dividing, a condition called senescense, a major factor in aging and disease. Senolytic drugs selectively eliminate these dying cells. In the lab, with naturally aging mice, doctors combined the senolytic drug, dasatinib, with the antioxidant quercetin, and found the combination prevented cell damage, delayed physical dysfunction, and extended lifespan. In a second phase of the study, dasatinib plus quercetin selectively killed senescent cells and slowed deterioration in walking speed, endurance, and grip strength. Doctors said senolytics including quercetin may enhance lifespan in older people, cancer survivors, and in other senescence-related conditions. Quercetin and senolytic drugs: Nature Medicine; July 2018, Vol. 24, 1246-12-56 Tocotrienol vitamin E and Alzheimer's disease. In the lab, doctors gave mice with Alzheimer's disease (AD) 27 mg of palm-oil derived tocotrienol vitamin E per pound of body weight, per day, or palm oil with no vitamin E. After 10 months, the groups performed daily tasks such as swimming and running over a two-week period. Those in the tocotrienol group showed improved exploratory activity, better memory, object recognition, and increased learning capacity. The tocotrienol group also had fewer abnormalities in brain tissue. Discussing the findings, doctors said tocotrienols may help regulate chemical reactions in the metabolic pathways of cells associated with Alzheimer's disease. Reference: Journal of Alzheimer's Disease; 2018, Vol. 64, No. 1, 249-67 Page 22 The Willner Window Product Reference Catalog, Winter 2019 Since 1911 • Willner Chemists: The Nutritional Supplement Professionals Ashwagandha Root 1:1.5 - 1 fl oz - Product Code: 57008 90 Veggie Caps - Product Code: 67465 Who would benefit from this supplement? • Those suffering from fatigue, stress, immune system problems, chronic fatigue syndrome, recovery from illness and auto-immune disorders. Ashwagandha is an adaptogenic herb, similar to ginseng, but it is less heating, “yang” or simulating than Panax ginseng. Ashwagandha is known as the “Ayurvedic” Ginseng. It is indicated for the same types of conditions as Ginseng, but Ashwagandha is not heating, Yang or stimulating like Ginseng (Panax varieties). It is used preventatively for those who have difficulty replenishing the energy they expend, and want to avoid burn out. Burnout from unrelenting stress can take the form of immune breakdown (colds, flu), headaches, irritable bowel, blood sugar swings and any other genetic, predispositional or constitutional weakness. Ashwagandha gives additional life force or Chi to help adapt to the stresses at hand. It can also be used as a restorative for those who have already burned out. Ashwagandha, as part of a rejuvenation treatment plan is effective in chronic fatigue syndrome, depression, debility, recovery from wasting diseases, chemotherapy and helps while one is in emotional recovery therapy. Ashwagandha is also indicated specifically in autoimmune disorders. It helps immunity to self modulate. It also has an affinity to help chronic neuro-muscular disorders such as fibromyalgia and multiple sclerosis (MS). Ingredients: Phyto-Tech™ Ashwagandha Root Liquid Extract contains the following: Fresh Organic Ashwaganda Root (Withania somnifera), Grain Alcohol, Deionized Water. Phyto-Tech™ Ashwagandha Root Veggie Caps contain, in each capsule, Organic Ashwagandha Root, 380 mg and selectively imported Ashwagandha Root Extract (1.5% Vithanaloids), 95 mg. The capsule contains modified vegetable cellulose. Certified organic. Dosage: Liquid Extract: 30 drops, 1-3 times per day or as directed in juice or water. Capsule: 1 veggie cap, 1-3 times a day. The fluid extract may contain a smal amount of herbal precipitate due to the strength of the preparation. Complimentary Formulas: • Phyto-Tech™ Adaptogen Complex • Phyto-Tech™ Ginseng Energy Blend Astragalus Root As a long term tonic, Astragalus helps boost deep immunity and resistance. Astragalus Root 1:3 - 1 fl oz - Product Code: 56949 Astragalus Root, 460 mg 90 Veggie Caps - Product Code: 60340 Who would benefit from this supplement? • Those who get sick easily or suffer from chronic health problems. It is especially useful for those undergoing chemotherapy. “You may already be accustomed to taking echinacea at the first sign of a cold or flu, or when people around you are getting sick. How is astragalus different? Like echinacea, Astragalus not only helps prevent colds and flu but shortens the course of a bug once it has set in. Astragalus can also be used as a long-term preventive and restorative herb, both to prevent illness and to renew energy and vitality once an acute illness hs passed. Scientific evidence salso suggests that astragalus may be one of the most important herbs for strengthening the immune system against serious diseases, including cancer.” (McCaleb, Robert, et al, The Encyclopedia of Popular Herbs, The Herb Research Foundation, Prima Health, 2000) The indications listed for Astragalus include the following: • Colds and flu, chronic respiratory problems such as bronchitis, digestive ailments, susceptibility to infectious disease, recovery after illness, general weakness and fatigue, cancer. The active constituents include polysaccharides (glucans), saponins (astragalosides), flavonoids and phytosterols, all of which contribute to the positive actions of Astragalus. It increases the number of stem cells in bone marrow and lymph tissue and encourages their development into active immune cells. It appears to help trigger immune cells from a “resting” state into heightened activity. One study showed Astragalus root helps promote and maintain respiratory health. It also enhances the body’s production of immunoglobulin and stimulates macrophages. Astragalus can help activate T-cells and natural killer (NK) cells. Astragalus stimulated NK-cell activity of human peripheral blood lymphocytes and restored steroid-inhibited NK-cell activity in another study. Traditionally, many herbalists feel Astragalus is best used when not acute. In other words, use it in between acute episodes in order to boost immunity and avoid frequent acute episodes. Astragalus is indicated for those who get sick frequently, for illnesses that do not resolve in a reasonable time, for those who get sick time after time. It is also indicated for those using antibiotics frequently. Think of it as an herbal flu shot, so take it before the immune season begins, especially for the elderly, the young and the immune suppressed. Dosage: 20-60 drops, 2-3 times per day or as needed in juice or . . . continued on page 23 Important Notice: The information given here is designed to help you make informed decisions about your health, and the proper use of dietary supplements. It is not intended as a substitute for medical advice, nor a substitute for any treatment that may have been prescribed by your doctor. If you have a medical problem, you should seek medical help. Products described herein are not intended to diagnose, treat, cure or mitigate disease. Product Reference Guide: Willner Chemists Phyto-Tech™ Herbal Supplements Preliminary Research Linking Ginkgo Biloba, Quercetin, Tocotrienol to Alzheimer's and Dementia Good results in the lab can lead to larger human trials and, hopefully, positive results. Here are some of the most promising recent findings from lab studies that might lead to effective treatments for various types of dementia. Willner Chemists Product Recommendations by Arnie Gitomer Ginkgo Biloba Capsules 60 mg. by Willner Phyto-Tech™ Product Number: 60131 Quercetin 500 mg. Capsules by Jarrow Product Number: 23123 Red Palm Tocotrienol 50 mg by NOW Product Number: 67909