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• Willner Chemists •

the nutritional supplement professionals

composition of nerve cell membranes.

Studies have shown that EPA and DHA influence:

• The fluidity of brain cell membranes.

• Neurotransmitter synthesis.

• Neurotranmitter binding.

• Signal transmission.

• The activity of key enzymes that break down

neurotransmitters like serotonin, epinephrine, dopamine,

and norepinephrine.

Clinical studies with supplemental EPA+DHA from fish oils

in patients with a variety of psychological conditions including

attention deficit disorder (ADD) and depression validate the

importance of supplementation to boost EPA+DHA levels.

Fish oils also appear to be important in protecting against age-

related mental decline and Alzheimer’s disease.

New Data:

While research has already established that B vitamin

supplements and omega-3 fatty acids can help slow mental

decline in older people with memory problems, the

interaction between these two nutritional approaches has

never really been examined until now. An international team

led by Oxford University and United Arab Emirates University

has now found that having higher levels of omega-3 fatty acids

in the brain boost the benefits of B vitamins in mild cognitive

function. The team studied more than 250 people with mild

cognitive impairment (MCI) in Oxford. MCI reflects an

intermediate stage between the expected cognitive decline of

normal aging and the more serious decline of dementia.

People with mild cognitive impairment can have problems

with memory, language, thinking and judgment, but generally

not to a degree to cause significant problems in their day-to-

day life and usual activities. Mild cognitive impairment may

increase the risk of later progressing to Alzheimer’s disease or

other dementia, but not everyone with Mild cognitive

impairment progresses to dementia.

At the start of the study, each person was given a set of tests

to measure their cognition, and had a blood test to determine

the levels of the omega-3 fatty acids EPA and DHA in the their

blood. The participants were split into two randomly selected

groups, who received either a B-vitamin supplement or a

placebo pill over two years. Their cognitive performance was

also measured and the results compared with the baseline

results from the start of the study.

What the researchers found was that for people with low

levels of EPA+DHA, the B vitamin supplement had little to

no effect. But for those with high baseline EPA+DHA levels,

the B vitamins were very effective in preventing cognitive

decline compared to the placebo.

These esults are game changing

because they show a clear

interaction and that B vitamins

only slow the rate of brain atrophy

in Mild cognitive impairment in

those with a good level of

EPA+DHA. The team of

researchers are now designing a

study to actually test the

combination of B vitamins and

EPA+DHA in slowing the

conversion from Mild cognitive

impairment to Alzheimer’s disease.

Commentary:

Here is something that is very

important to for people to know.

Drugs do not work to improve

mild cognitive impairment. In a

systemic review funded by the

Drug Efficacy and Safety Network

of the Canadian Institute of Health

Research, eight randomized

clinical trials and 3 companion

reports were used to evaluate the

safety and efficacy of various drugs

referred to as “cognitive enhancers” (donepezil [Aricept],

rivastigmine [Exelon], galantamine [Razadyne], or memantine

[Nemenda]) on mild cognitive impairment. Results showed

these drugs did NOT improve cognition or function among

patients with Mild cognitive impairment and were associated

with a greater risk of side effects especially nausea, diarrhea

and vomiting than placebo. Researchers concluded

“Our

findings do not support the use of cognitive enhancers for

mild cognitive impairment.”

The bottom line is that the key goal to boosting brain

function is to bath the brain in “super nutrition,” as numerous

studies have shown that brain function is directly related to

nutritional status. High nutritional status equals higher mental

function.

The key dietary factors that reduce the risk of dementia and

Alzheimer’s disease from population-base studies are higher

fish consumption (and omega-3 fatty acids), monounsaturated

fatty acids (primarily from olive oil), light to moderate alcohol

use (primarily red wine), and increased non-starchy vegetable

and fruit consumption. It is likely that it is the combination of

all of these factors that provide the highest degree of

protection versus any single dietary factor. One food that is

particularly helpful are blueberries or blueberry extracts. In

animal studies researchers have found that blueberries help

protect the brain from oxidative stress and memory loss.

In addition to diet, it makes sense to take a high potency

multiple vitamin and mineral formula to supply the brain with

super nutrition it makes sense to also take 1,000 to 3,000 mg

of EPA and DHA (combined) from a quality fish oil. Higher

intakes of these omega-3 fatty acids are associated with higher

mood and mental function scores.

If symptoms of mental deterioration are definitely present in

a person 50 years and older I would recommend taking

phosphatidylserine. Phosphatidylserine (PS) is a critical

nutrient for anyone with impaired mental function. PS plays a

major role in determining the integrity and fluidity of brain cell

membranes. Over a dozen double-blind studies have shown

phosphatidylserine to improve in mental function, mood, and

behavior in patients with degenerative brain disorders. The

recommended dosage is 100 mg three times daily.

Reference:

Oulhaj A, JernerÇn F, Refsum H, Smith AD, de Jager CA.

Omega-3 Fatty Acid Status Enhances the Prevention of

Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

J Alzheimers Dis. 2016 Jan 6;50(2):547-57.

anthocyanins, proanthocyanidins, and other fatty acids. Studies have

shown that acai has anti-inflammatory, antioxidant, and apoptic

(programmed cell death). effects A study published in the Journal of

Agricultural and Food Chemistry, showed extracts of Acai berries trig-

gered apostisis in up to 86 percent of leukemia cells tested.

Mangosteen (Garcinia magostana) is a plant native to Southeast

Asia. Studies reveal that xanthones from the fruit hulls of mangos-

teen have antioxidant, antibacterial, antifungal, and anti?inflammato-

ry properties. In one study mangosteen’s xanthones significantly

inhibited the growth of leukemia cells. One xanthone in particular,

alpha?mangostin, showed complete inhibition of leukemia cells

through the induction of apoptosis (programmed cell death). Other

studies indicate xanthones from mangosteen inhibit the activities of

COX?1 and COX?2 enzymes, prevent oxidative damage of LDL cho-

lesterol, have cytotoxic effects on liver cancer cells, and are antipro-

liferative, antioxidative, and apoptic against breast cancer cells.

Goji Berry (Lycium barbarum) polysaccharides exhibit anti-tumor,

immune enhancing and liver-protective properties. Studies suggest

that Goji polysacharides have positive effects when used with con-

ventional cancer treatments. A 1994 study done in China on

patients with a variety of cancers revealed that patients who were

given Goji Berry polysaccharides along with their conventional can-

cer treatment had a 40.9 percent response rate to the treatment,

while patients who received conventional treatment without the Goji

Berry supplement had only a 16.1 percent response rate.

Additionally the Goji Berry supplemented patients experienced

longer remissions and had a significant increase in natural killer cell

activity. Goji berries contain high levels of Zeaxanthin, a carotenoid

necessary for healthy vision that is present in high amounts in the

macula of the human eye. The Zeaxanthin in Goji berries is a natu-

rally esterifed zeaxanthin which has been proven to cause a higher

increase in plasma levels than the non-esterified form contained in

many supplements. Researchers have concluded that Goji is one of

the best antioxidants to promote healthy aging.

Pomegranate (Punica granatum) contains thousands of phytochem-

icals including anthocyananins, ellagic acid derivatives, catechins and

procyandins, flavonols, fatty acids and sterols. Human studies show

that pomegranate polyphenols and their metabolites offer protection

against various diseases. Pomegranate increases nitric oxide produc-

tion in the endothelial cells of the vascular system protecting against

cardiovascular disease. Studies show consumption of the juice bene-

fits patients with carotid artery stenosis, those with hypertension, and

those with coronary heart disease. Pomegranate has been heavily

studied in the treatment of prostate cancer. In one study when men

with aggressive prostate cancer were given pomegranate juice daily

after treatment by surgery or radiation, there was over a four-fold

prolonged delay in prostate specific antigen (PSA) doubling time,

and the rate of PSA rise was reduced by 50% over the course of just

one year. Numerous other studies demonstrate pomegranate inhibits

inflammation, slows cartilage loss in arthritis, improves sperm health,

and increases the overall antioxidant capacity of the blood.

1 fl oz - Prod Code: 57551

Antiox Phyto Complex II

Some of the most powerful, broad-spectrum antioxidants are

those found in plants. This supplement contains a blend of

several of the most potent plant-derived phyto-antioxidants

available, in a high potency, professional strength veggi cap.

Who would benefit from this supplement? Anyone needing antiox-

idant protection as well as those looking for enhanced immunity,

those with cardiovascular problems, stress, and concerns about envi-

ronmental pollution. It is also an essential component of any “anti-

aging” supplement regimen.

Phyto-Tech™ Antiox Phyto Complex II Capsules contains 375 mg

of the following: Acai Berry Concentrate, Mangosteen Fruit Extract,

Goji Berry, Pomegranate, Green Tea Leaf Extract, Grape Skin Extract,

Grape Seed Extract.

Description: Phyto-Tech Antiox Phyto Complex II is a blend of

powerful plant-derived (phyto) antioxidants. Most health problems

are either directly or indirectly related to oxidative (free-radical)

damage. While vitamins and minerals (vitamin C, vitamin E and sele-

nium, for example) are antioxidants, it is now recognized that phy-

toantioxidants, rich in a broad spectrum of flavonoids, polyphenols,

anthocyanidins, etc are the most powerful.

Indications: Who might benefit from this herbal supplement?

Those who desire protection against everyday toxins--dietary, envi-

ronmental and chemical. Those with current health problems, those

under high amounts of stress, smokers or those exposed to second-

hand smoke, and anyone who lives or is exposed to a toxic lifestyle.

Those who are at risk to the various degenerative diseases associated

with aging, including cancer, cardiovascular disease, cognitive

impairment, Alzheimer’s disease, immune dysfunction, cataracts,

and macular degeneration. Those who want to live a longer, healthi-

er life.

Ingredients: Acai Berry Extract 4:1, 75 mg; Mangosteen Fruit

Extract, 75 mg (10% Mangostin); Goji Berry Extract 75 mg (40%

Polysaccharides); Pomegranate 75 mg, (40% Ellagic Acid); Green Tea

Leaf Extract 30 mg (98% Polyphenols, 50% EGCG); Grape Skin

Extract, 30 mg (50% Polyphenols); Grape Seed Extract,15 mg (95%

Proanthocyanidin); Cellulose Modified Vegetable,

Cautions: Pregnancy, Nursing

Dosage: Take one 375 mg veggie capsule once or twice a day.

References: Acai Berry (Euterpe oleraceae) is the fruit of a palm

tree native to South America. The pulp and skin of acai are rich in

anthocyanins, proanthocyanidins, and other fatty acids. Studies have

shown that acai has anti-inflammatory, antioxidant, and apoptic

(programmed cell death). effects A study published in the Journal of

Agricultural and Food Chemistry, showed extracts of Acai berries trig-

gered apoptosis in up to 86 percent of leukemia cells tested.