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The Willner Window Product Reference Catalog, Spring, 2015
since 1911
• Willner Chemists •
the nutritional supplement professionals
Eurofins; NSF International; Midwest
Laboratories, National Center for Natural
Products Research at the University of
Mississippi, as well as numerous others.
Regarding testing methodology, I have
attached a sampling of the primary nationally
and internationally accepted methods for the
testing of the various botanicals you tested
and some guidance on what should be test-
ed. While these tests can be applied to fin-
ished products, it is important to note they
were specifically designed for raw materials
and extract that go into finished products.
Thus, finished product values may vary but
should be close to the values provided.
While it is likely such analytical methodolo-
gies are not familiar to you, they are familiar
to any analytical chemist and can guide
future analytical work that is scientifically
valid, whereas the current DNA barcoding
technology is likely not scientifically valid for
determining the identity of botanical ingredi-
ent identity in extract products. Similarly,
without an ability to do a quantitative assay,
it is not appropriate for determining if a
product is “contaminated” as acceptable lim-
its of foreign organic matter will potentially
show up as “contaminants”, when in reality
they may not be. In conjunction with the
American Botanical Council (ABC), Austin,
TX and the University of Mississippi, Oxford,
MS, AHP is engaged in an active review of
herbal ingredients with the express purpose
of identifying confirmed adulterations, raising
awareness of such problems within industry,
and to providing solutions, such as articulat-
ing the appropriate testing methodologies
that should be conducted, as we have done
above. This program has broad support from
industry and academic institutes internation-
ally showing that a significant segment of the
herbal products market is committed to the
quality and integrity of their products. More
information about this program can be
accessed at:
s=1418665529&signature=003bdb220a482
eabe942ba7e299089c4
&ts=1423272362&signature=49a186414e8
b367db4d970c708a6deb3
We hope this information is helpful. If we
can provide further guidance on botanical
related issues, please let us know. We wish
you well in your work.
Sincerely,
Roy Upton, Executive Director
American Herbal Pharmacopoeia
831-461-6317
Garlic Powder
Identity: Macrosocpic, microscopic, HPTLC
or HPLC fingerprint profile according to USP.
Potency: Calculated according to method-
ology of USP compared against label claim.
Ginkgo Extract
It is rare to find a pure ginkgo leaf product
on the market. The industry standard is
based on a German extract that has been
subjected to widespread clinical investiga-
tion.
Identity: HPLC Fingerprint according to
AHP or USP monographs and specifically
including measures to ensure the absence of
spiked rutin, quercetin, or sophora.
Potency: Flavonol Glycosides: Total flavonol
glycosides 22-27% (wt/wt) based on the sum
of
quercetin, kaempferol and isorhamnetin in
the following general ratios:
Quercetin minimum 9.5% (wt/wt)
Kaempferol minimum 10.5% (wt/wt)
– the Q standing for CoQ10 the other letters
for SYMptoms, BIomarker status, and long-
term Outcome (hospitalisations/mortality).
A total of 420 patients with moderate to
severe CHF were randomly assigned in a 2-
year trial to either CoQ10 100 mg 3 times
daily or placebo, in addition to standard
therapy. The primary short-term endpoints at
16 weeks were changes in New York Heart
Association (NYHA) functional classification,
6-min walk test, and levels of a biomarker
linked to heart function (N-terminal pro–B
type natriuretic peptide). The primary long-
term endpoint at 2 years was the number of
major cardiovascular events (e.g., a heart
attack or stroke).
The results showed that in the CoQ10
group there was a significant improvement in
CHF as noted by better NYHA class after 2
years. Most importantly, only 15% of the
patients in the CoQ10 group had a major
cardiovascular event compared to 26% in the
placebo group. Death due to a cardiovascu-
lar event occurred in 9% in the CoQ10
group vs. 16% in the placebo group; overall
mortality was 10% in the CoQ10 group vs.
18% in the placebo group. There were no
side effects with CoQ10 or placebo supple-
mentation.
Q-SYMBIO is the first clinical trial with
adequate size, dosage of CoQ10, and dura-
tion of follow-up to evaluate the efficacy of
CoQ10 on morbidity and mortality in CHF.
The major endpoint showed that CoQ10
produced a 43% reduction in the risk of
dying from a heart attack or stroke.
Ginger for Migraine
Study shows that ginger powder as
effective as the drug sumatriptan,
with fewer side effects.
People with migraines have severe
headaches with other physical symptoms. In
this study, at the onset of acute migraine, 100
adults took 50 mg of the standard migraine
drug, sumatriptan, or 250 mg of ginger pow-
der. Participants kept track of when the
headache started and its severity over time.
After one month, a similar majority in both
groups reported 90 percent pain relief two
hours after taking treatment. Twenty percent
of the sumatriptan group had side effects
including dizziness, sedation, vertigo, and
heartburn, compared to 4 percent in the gin-
ger group reporting an upset stomach, mak-
ing ginger as effective and safer for migraine.
Reference: Phytotherapy Research; 2014,
Vol. 28, No. 3, 412-5
CoQ10 Study Yields Important
Results And Considerations
Introduction
One of the most important nutrients for
heart health is coenzyme Q10 (CoQ10). Its
role in the heart is similar to the role of a
spark plug in a car engine. Just as the car
cannot function without that initial spark, the
heart cannot function without CoQ10.
Although the body can make CoQ10, con-
siderable research shows significant benefits
with supplementation in various health issues
and in people taking cholesterol-lowering
drugs (e.g., statins like Lipitor and Crestor).
Results from a very detailed study conduct-
ed at research centers throughout Europe
and Asia not only show beneficial effects in
patients with chronic heart failure (CHF), but
also provides some insight on the importance
of effective dosage of CoQ10.
Background Data:
CoQ10 is an essential component of the
mitochondria, where it plays a major role in
energy production. Deficiency of CoQ10 can
be a result of impaired production due to
nutritional deficiencies, a genetic or acquired
defect in CoQ10 synthesis (e.g., statin drugs
block CoQ10 formation), or increased tissue
needs. Cardiovascular diseases, including
angina, hypertension, mitral valve prolapse,
and CHF, are examples of diseases that
require increased tissue levels of CoQ10. In
addition, many elderly people may have
increased CoQ10 requirements. In a 5-year
double-blind placebo-controlled study of
healthy elderly people, daily supplementa-
tion with a combination of CoQ10 (200 mg)
and selenium (200 mcg) reduced cardiovas-
cular mortality by 46%.
In the treatment of chronic heart failure,
studies have most often used CoQ10 as a
support aid (adjunct) to conventional drug
therapy. The improvements noted with
CoQ10 were actually found to be more posi-
tive than those obtained from conventional
drug therapy used alone in these studies.
However, the studies have not yet answered
several important questions including what is
the optimal form and dosage of CoQ10 and
what effect does CoQ10 have on reducing
mortality in patients with CHF.
New Data:
CoQ10 was evaluated as an adjunctive
treatment of CHF in a randomized, double-
blind, multicenter trial known as Q-SYMBIO
. . . continued from page 8
Looking for the perfect
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A Broad-Spectrum, Complete, Balanced Multivitamin
Multimineral Supplement
• Full complement of water-soluble and fat-soluble vitamins
• Full complement of trace minerals
• Includes full daily dose of Calcium and Magnesium
• Also contains accessory nutrients such as CoQ10, Grape Seed
Extract, Choline, Inositol, PABA, Lutein, Lycopene, etc.
• Flexible dosage: two to four tablets per day
• Convenient: everything you need in one product
• Suitable for use as “foundation” formula, to which other
supplement can be added as needed
• Regular and Iron-Free.
Willvite, Code 30439, 120 Tablets
Willvite, Code 44384, Iron-Free, 120 Tablets
Willner PhytoTech
Ginger Root
This herb supports the digestive and
circulatory systems, and has been shown to be
especially helpful in alleviating nausea and
equilibrium problems.
Who can benefit from this supplement? Those
who suffer from nausea (pregnancy, motion sick-
ness), digestive insufficiency and poor circula-
tion.
Phyto-Tech™ Ginger Root 1:1.5 Liquid Extract
provides 667 mg of certified organic Fresh
Ginger Root per 30 drops.
1 fl oz - Prod Code: 56995
Also available as a veggie cap:
Each Phyto-Tech Ginger Capsule contains
500 mg of certified organic Ginger Root
(Zingiber officinalis).
(Product code: 60127)
90 Veggie Caps - Prod Code: 60127
List: $12.60 ~ Discount: $10.08
See pages 96-103 for
more information
Natural Factors
BioQ10
BioQ10 SA™ Coenzyme
Q10 is derived from
100% all-natural sourced
materials and specially
formulated in a propri-
etary process to enhance
bioavailability. A specific
protein extracted from
non-GMO soy is used in this process that
acts as an emulsifier and carrier of the
CoQ10. Bioavailability studies have shown
BioQ10 SA in soft gelatin capsules led to
higher blood levels of ubiquinol (active
CoQ10) than other forms of CoQ10 includ-
ing ubiquinol.
Willner Prod. Code: 60041
BioQ10, 60 Softgels
List: $34.95 ~ Sale: $24.47
Note: All Natural Factors products, includ-
ing other CoQ10 formulas, are on sale at
30% off list price until May 15th.
. . . continued on page 14
