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The Willner Window Product Reference
since 1911
• Willner Chemists •
the nutritional supplement professionals
Nature’s Answer
CoQ10.
PQQ also supports neuronal health through
intracellular targets that are distinct from
CoQ10 and are largely unprecedented in the
realm of nutritional supplementation. For
example, PQQ maintains healthy levels of
DJ-1, a protein that plays a role in antioxi-
dant defenses in dopaminergic neurons.
PQQ also supports the biosynthesis of nerve
growth factor (NGF), an important signaling
molecule in the brain and sensory nerves.
Perhaps the most salient discovery over the
past two decades of research on PQQ and
neuronal function is its ability to balance acti-
vation of ionotropic glutamate receptors. The
N-methyl D-aspartate (NMDA) receptor is
the primary conduit for excitatory glutamate
neurotransmission and is regarded as an
important target for maintaining neuronal
health. PQQ supports synaptic and intracel-
lular responses by maintaining healthy
NMDA receptor activity.
Recent studies indicate that PQQ supports
cognitive function. In one study involving
rats, PQQ supplementation supported per-
formance in a water maze test. In a random-
ized, double blind study of 71 middle aged
individuals, PQQ supplementation over 12
weeks promoted mental processing. In the
same study, a combination of PQQ and
CoQ10 was more effective than either agent
alone.
PQQ offers wide range neural and cogni-
tive support, including antioxidant activity,
mitochondrial synthesis and nerve cell recep-
tor function. While additional clinical investi-
gations are necessary, existing evidence sug-
gests that PQQ provides powerful multifac-
eted neuroprotection.
Who might benefit from supplementation
with PQQ? Future research will no doubt
focus on the following health conditions:
• Cardiovascular Health
• Longevity and Aging
• Immune System Function
• Cognitive Decline, including Alzheimer’s
and Parkinson’s diseases
• Spinal and peripheral nerve damage
References:
(1) Pyrroloquinoline Quinone (PQQ): A
novel approach to neuroprotection. By Kelly
C. Heim, Ph.D. (http://www.pureencapsula-
tions.com/education-
research/newscaps/newscap-03-01-10)
(2) Life Extension Foundation Product
Literature. (Www.lef.org) (PQQ Caps with
BioPQQ®, etc)
(3) Reverse Brain Cell Death by Growing
New Mitochondria, by Michelle Flagg. Life
Extension Magazine, Nov 2011
(http://www.lef.org/magazine/mag2011/nov2
011_Reverse-Brain-Cell-Death-by-Growing-
New-Mitochondria_01.htm)
Loss of mitochondrial function is both a
cause and a consequence of aging, produc-
ing a vicious cycle of oxidative damage that
destroys brain cells. While antioxidant
intake is critical, researchers now recognize
it as only one part of a comprehensive pre-
ventive strategy.
The nutrient PQQ, essential for many
forms of life on Earth, comprises a powerful
strategy to combat brain aging. PQQ pro-
tects mitochondria from cumulative oxida-
tive damage and stimulates growth of
healthy new mitochondria, thereby restoring
youthful brain cell function.
PQQ’s effects on brain mitochondria, cou-
pled with its other beneficial neuroprotec-
tive characteristics, make it a natural solu-
tion for preserving brain function as you
age. Taken together with PQQ’s recently
discovered cardioprotection and well-estab-
lished immune enhancement, there is every
reason to include PQQ in your supplement
program.
(4) Rejuvenate Your Cells by Growing
New Mitochondria, by Kirk Stokel. Life
Extension Magazine.
(http://www.lef.org/magazine/mag2010/ss20
10_Rejuvenate-Your-Cells-Growing-New-
Mitochondria_01.htm)
PQQ Supplements are available from
Willner Chemists, from the following compa-
nies:
Pure Encapsulations
Life Extension
Jarrow Formulas
Quality of Life
To see a full listing, go to www.willner.com,
and enter “pqq” in the “Product Quick
Search” box on the upper left side of the
home page
Restless Legs Syndrome
Can Nutritional Supplements Play A
Role?
Restless legs syndrome is defined as “a
neurological disorder characterized by a peri-
odic need to move the legs in order to
relieve an unpleasant or uncomfortable sen-
sation in the legs. The symptoms are usually
worse in the evening or at night, and occur
primarily during periods of inactivity, such as
while lying down or sitting. In the United
States, an estimated 5–15% of the population
suffers from RLS, with older people being
affected more often than younger people.
The condition occurs frequently in the later
stages of pregnancy. RLS often interferes with
sleep, resulting in chronic sleep deprivation
and a reduced quality of life.” (Gaby, Alan R.,
MD. Nutritional Medicine. Alan R. Gaby,
M.D., 01/2011.)
What causes this condition? Stress can be a
factor, as is nicotine, or smoking, and alco-
hol. Certain dietary factors may cause the
problem as well, and I will elaborate on this
shortly. For those with reactive hypoglycemia,
improving blood glucose control can help.
Food allergies should be ruled out.
Those nutrients that have been associated
with restless leg syndrome include folic acid,
iron, magnesium, vitamin E, flavonoids and
vitamin C.
. . . continued on page 103
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