Page 14
The Willner Window Product Reference Catalog, Spring, 2013
since 1911
• Willner Chemists •
the nutritional supplement professionals
ly or indirectly related to oxidative (free-radical) damage. While vita-
mins and minerals (vitamin C, vitamin E and selenium, for example)
are antioxidants, it is now recognized that phytoantioxidants, rich in
a broad spectrum of flavonoids, polyphenols, anthocyanidins, etc are
the most powerful.
Phyto-Tech™ Antiox Phyto Blend contains the following: Acai
Berry 4:1, Mangosteen Extract, Goji Berry Extract, Pomegranate
40%, Glycerin Vegetable, Water Pure Deionized, Raspberry Flavor
Natural.
References: Acai Berry (Euterpe oleraceae) is the fruit of a palm
tree native to South America. The pulp and skin of acai are rich in
anthocyanins, proanthocyanidins, and other fatty acids. Studies have
shown that acai has anti-inflammatory, antioxidant, and apoptic (pro-
grammed cell death). effects A study published in the Journal of
Agricultural and Food Chemistry, showed extracts of Acai berries trig-
gered apostisis in up to 86 percent of leukemia cells tested.
Mangosteen (Garcinia magostana) is a plant native to Southeast
Asia. Studies reveal that xanthones from the fruit hulls of mangos-
teen have antioxidant, antibacterial, antifungal, and anti?inflammato-
ry properties. In one study mangosteen’s xanthones significantly
inhibited the growth of leukemia cells. One xanthone in particular,
alpha?mangostin, showed complete inhibition of leukemia cells
through the induction of apoptosis (programmed cell death). Other
studies indicate xanthones from mangosteen inhibit the activities of
COX?1 and COX?2 enzymes, prevent oxidative damage of LDL cho-
lesterol, have cytotoxic effects on liver cancer cells, and are antipro-
liferative, antioxidative, and apoptic against breast cancer cells.
Goji Berry (Lycium barbarum) polysaccharides exhibit anti-tumor,
immune enhancing and liver-protective properties. Studies suggest
that Goji polysacharides have positive effects when used with con-
ventional cancer treatments. A 1994 study done in China on
patients with a variety of cancers revealed that patients who were
given Goji Berry polysaccharides along with their conventional can-
cer treatment had a 40.9 percent response rate to the treatment,
while patients who received conventional treatment without the Goji
Berry supplement had only a 16.1 percent response rate.
Additionally the Goji Berry supplemented patients experienced
longer remissions and had a significant increase in natural killer cell
activity. Goji berries contain high levels of Zeaxanthin, a carotenoid
necessary for healthy vision that is present in high amounts in the
macula of the human eye. The Zeaxanthin in Goji berries is a natu-
rally esterifed zeaxanthin which has been proven to cause a higher
increase in plasma levels than the non-esterified form contained in
many supplements. Researchers have concluded that Goji is one of
the best antioxidants to promote healthy aging.
Pomegranate (Punica granatum) contains thousands of phytochem-
icals including anthocyananins, ellagic acid derivatives, catechins and
procyandins, flavonols, fatty acids and sterols. Human studies show
that pomegranate polyphenols and their metabolites offer protection
against various diseases. Pomegranate increases nitric oxide produc-
tion in the endothelial cells of the vascular system protecting against
cardiovascular disease. Studies show consumption of the juice bene-
fits patients with carotid artery stenosis, those with hypertension, and
those with coronary heart disease. Pomegranate has been heavily
studied in the treatment of prostate cancer. In one study when men
with aggressive prostate cancer were given pomegranate juice daily
after treatment by surgery or radiation, there was over a four-fold
prolonged delay in prostate specific antigen (PSA) doubling time,
and the rate of PSA rise was reduced by 50% over the course of just
one year. Numerous other studies demonstrate pomegranate inhibits
inflammation, slows cartilage loss in arthritis, improves sperm health,
and increases the overall antioxidant capacity of the blood.
1 fl oz - Prod Code: 57551
Antiox Phyto Complex
Antiox Phyto Complex
Some of the most powerful, broad-spectrum antioxidants are
those found in plants. This supplement contains a blend of
several of the most potent plant-derived phyto-antioxidants
available, in a liquid filled, professional strength veggi cap.
Who would benefit from this supplement? Anyone needing
antioxidant protection as well as those looking for enhanced immu-
nity, those with cardiovascular problems, stress, and concerns about
environmental pollution. It is also an essential component of any
“anti-aging” supplement regimen.
Phyto-Tech™ Antiox Phyto Complex contains the following: Acai
Berry Concentrate, Mangosteen Extract, Goji Berry, Pomegranate,
Green Tea Extract, Grape Skin Extract, Grape Seed Extract. Each 250
mg capsule contains the equivalent of 2,900 mg of raw herb.
Description: Phyto-Tech Antiox Phyto Complex is a blend of pow-
erful plant-derived (phyto) antioxidants. Most health problems are
either directly or indirectly related to oxidative (free-radical) damage.
While vitamins and minerals (vitamin C, vitamin E and selenium, for
example) are antioxidants, it is now recognized that phytoantioxi-
dants, rich in a broad spectrum of flavonoids, polyphenols, antho-
cyanidins, etc are the most powerful.
Indications: Who might benefit from this herbal supplement?
Those who desire protection against everyday toxins--dietary, envi-
ronmental and chemical. Those with current health problems, those
under high amounts of stress, smokers or those exposed to second-
hand smoke, and anyone who lives Phyto-Tech™ Antiox Phyto
Complex is a blend of powerful plant-derived (phyto) antioxidants.
Most health problems are either directly or indirectly related to
oxidative (free-radical) damage. While vitamins and minerals (vita-
min C, vitamin E and selenium, for example) are antioxidants, it is
now recognized that phytoantioxidants, rich in a broad spectrum of
flavonoids, polyphenols, anthocyanidins, etc are the most
powerful.or is exposed to a toxic lifestyle. Those who are at risk to
the various degenerative diseases associated with aging, including
cancer, cardiovascular disease, cognitive impairment, Alzheimer’s
disease, immune dysfunction, cataracts, and macular degeneration.
Those who want to live a longer, healthier life.
Ingredients: Acai Berry 4:1, Mangosteen Extract, Goji Berry
Extract, Pomegranate 40%, Green Tea Extract, Grape Skin Extract,
Grape Seed Extract, Olive Oil EV Cold Press, Cellulose Mod
Vegetable, Beeswax, Tocopherols Mixed, Chlorophyll
Cautions: Pregnancy, Nursing
Dosage: Take one liquid filled veggie capsule once or twice a day.
References: Acai Berry (Euterpe oleraceae) is the fruit of a palm
tree native to South America. The pulp and skin of acai are rich in
anthocyanins, proanthocyanidins, and other fatty acids. Studies have
shown that acai has anti-inflammatory, antioxidant, and apoptic (pro-
grammed cell death). effects A study published in the Journal of
Agricultural and Food Chemistry, showed extracts of Acai berries trig-
gered apostisis in up to 86 percent of leukemia cells tested.
Mangosteen (Garcinia magostana) is a plant native to Southeast
Asia. Studies reveal that xanthones from the fruit hulls of mangos-
teen have antioxidant, antibacterial, antifungal, and anti?inflammato-
ry properties. In one study mangosteen’s xanthones significantly
inhibited the growth of leukemia cells. One xanthone in particular,
alpha?mangostin, showed complete inhibition of leukemia cells
through the induction of apoptosis (programmed cell death). Other
studies indicate xanthones from mangosteen inhibit the activities of
COX?1 and COX?2 enzymes, prevent oxidative damage of LDL cho-
lesterol, have cytotoxic effects on liver cancer cells, and are antipro-
liferative, antioxidative, and apoptic against breast cancer cells.
Goji Berry (Lycium barbarum) polysaccharides exhibit anti-tumor,
immune enhancing and liver-protective properties. Studies suggest
that Goji polysacharides have positive effects when used with con-
ventional cancer treatments. A 1994 study done in China on
patients with a variety of cancers revealed that patients who were
given Goji Berry polysaccharides along with their conventional can-
cer treatment had a 40.9 percent response rate to the treatment,
while patients who received conventional treatment without the Goji
Berry supplement had only a 16.1 percent response rate.
Additionally the Goji Berry supplemented patients experienced
longer remissions and had a significant increase in natural killer cell
activity. Goji berries contain high levels of Zeaxanthin, a carotenoid
necessary for healthy vision that is present in high amounts in the
macula of the human eye. The Zeaxanthin in Goji berries is a natu-
rally esterifed zeaxanthin which has been proven to cause a higher
increase in plasma levels than the non-esterified form contained in
many supplements. Researchers have concluded that Goji is one of
the best antioxidants to promote healthy aging.
Pomegranate (Punica granatum) contains thousands of phytochem-
icals including anthocyananins, ellagic acid derivatives, catechins and
procyandins, flavonols, fatty acids and sterols. Human studies show
. . . continued on page 16
Important Notice: The information given here is designed to help you make informed decisions about your health, and the proper use of dietary supplements. It is
not intended as a substitute for medical advice, nor a substitute for any treatment that may have been prescribed by your doctor. If you have a medical problem, you
should seek medical help. Products described herein are not intended to diagnose, treat, cure or mitigate disease.
free radicals. Cross linking and glycation of
connective tissue proteins, such as collagen,
results in the formation of advanced glycation
end products (AGE) which accumulate with
age, and induce stiffening of cartilage and
extracellular matrix, resulting in cataracts in
the eyes and arthritis in the joints.
In the cardiovascular system aging is associ-
ated with a decrease in elasticity and an
increase in stiffness of the arteries. Glucose
tolerance progressively declines with age,
and there is a high prevalence of type 2 dia-
betes in the aging population. Kidney func-
tions, liver functions and sensory perception
also deteriorate with age. Malabsorption of
vital nutrients in the elderly, results in a com-
promised immune system and lowered resist-
ance to infection. Hormonal imbalances
associated with menopause and aging, affect
bone turnover, muscle mass, strength and
mental capabilities. In males, aging is often
associated with impaired prostate functions.
Recent research findings lend credence to
the fact that metabolism, gene expression,
and aging intersect at the molecular level.
The indices of aging have been linked to the
morphology of cellular DNA. A telomere is a
region of highly repetitive DNA at the end of
a linear chromosome that functions as a dis-
posable buffer which is gradually depleted
during the continued cell replication. Many
aging-related diseases are linked to shortened
telomeres.
A major breakthrough in the anti-aging
research commenced with the identification
of a few genetic pathways that are regulatory
master keys in the aging process, a major one
being the Silent information regulator 2 (Sir2)
pathway. Sir2 family of proteins (sirtuins) are
NAD-dependent protein deacetylase or ADP-
ribosyltransferase that have been shown to
regulate aging and longevity in a number of
model organisms including yeast and round
worms, in response to nutritional and hor-
monal cues. An analogous gene, SIRT1 was
located in humans. Sirtuins play in the modi-
fication of nuclear receptors and the corre-
sponding age-associated metabolic diseases.
Nuclear receptors sense a variety of environ-
mental triggers, including dietary components
and steroid hormones, and influence meta-
bolic functions and the aging process.
BIOMARKERS OF AGING AND
NUTRITIONAL INTERVENTIONS TO
SUPPORT HEALTHY AGING
Biomarkers or physiological indices of aging
include lean body mass, bone density,
strength, BMR (basal metabolic rate), body
fat percentage, aerobic capacity, blood pres-
sure, insulin sensitivity, cholesterol/HDL ratio,
memory / cognitive functions, immune func-
tions and body temperature regulation.
There is an increasing amount of scientific
evidence to support the beneficial “anti-
aging” effects of several phytonutrients at the
molecular level. For example, plant fla-
vanoids inhibit the age-related atherosclerotic
deposits in ani-
mals by influenc-
ing vascular cell
adhesion mole-
cule-1 (VCAM-1)
and monocyte
chemotactic
protin-1 (MCP-1)
gene expression
(Lee, CH et al;
2001). The
micronutrient
mineral seleni-
um, long known
to offer protec-
tion against several forms of cancer, was
shown to exert its anti-senescence influence
in animal models, at the genetic level. In
vitro experiments revealed that selenium sup-
plementation significantly increased cellular
telomerase activity and hTERT (human
telomerase reverse transcriptase) gene
expression and augmented telomere length.
(Liu, Q et al.; 2003). SeleniumSelect ®1 (L-
selenomethionine), SelenoForce™ (selenium
enriched garlic), and MethySelene ® ) are
bioavailable sources of organic selenium. (1
Trademarks of Sabinsa Corporation)
A decline in insulin sensitivity is often
observed during aging. Obesity is also known
to lower insulin sensitivity (Escriva, F et al.;
2007). Dietary and lifestyle measures that
contribute to maintaining a healthy body
weight have anti-aging benefits as well.
Nutritional interventions designed to provide
ammunition against oxidative stress and posi-
tively influence the physiological indices of
aging, are key components of a healthy aging
regimen.
CALORIE RESTRICTION AND LIFE
SPAN
Calorie restriction (CR) by 30-40% of the
daily intake extends lifespan in a wide spec-
trum of organisms and is the only regimen
known to lengthen the lifespan of mammals
(Lin, SJ et al.; 2002) Studies in rhesus mon-
keys revealed that CR decreases body weight
and fat mass, improves glucoregulatory func-
tion, decreases blood pressure and blood
lipids, and decreases body temperature.
These effects may be responsible for the
effects of CR in delaying the onset of age-
related disease and maintaining function later
into life (Mattison, J.A. et al.; 2003). Calorie
restriction was found to enhance the expres-
sion of key metabolic enzymes associated
with protein renewal during aging (Spindler,
SR 2001). In Emory mice, dietary calorie
restriction had beneficial effects on lifespan,
eye lens cataract prevalence and progression,
plasma glucose levels and liver glutathione
levels (Taylor, A. et al.; 1995). Other studies
suggest that CR may alter gene expression for
gluconeogenic, glycolytic, and nitrogen-
metabolizing enzymes. CR may decrease
enzymatic capacity for glycolysis and increase
the enzymatic capacity for hepatic gluconeo-
genesis and the disposal of byproducts of
muscle protein catabolism. (Dhahbi JM et al.;
1999).
Calorie restriction is reported to reduce the
accumulation of advanced glycation end
products (AGE) in animal models (Lingelbach,
LB et al.; 2000) Age-related increase in
oxidative DNA damage to aortic cells in mice
is reported to be reduced by food restriction
(Guo, Z.M. et al.; 2001). Prevention of
excessive glycoxidation is suggested to con-
trol tissue alterations occurring in aging (Meli,
M. et al.; 2003) . Carbohydrate energy
restriction is reported to prevent oxidative
damage to brain cells sparked by exhaustive
exercise (de Oliveira SL et al.; 2003). The
neuroprotective effect of dietary restriction
and the administration of 2-deoxyglucose, a
non-metabolizable analog of glucose in a
cerebral ischemia model suggests that out-
come following stroke may be improved in
individuals who follow a regimen of reduced
food intake (Yu ZF, et al.; 1999)
The 'carnivore connection' is postulated to
play a critical role in the role of the glycemic
index of dietary carbohydrate in the evolu-
tion of insulin resistance and hyperinsuli-
naemia. Historically, humans consumed diets
rich in protein and complex carbohydrates
with low glycemic index, wherein insulin
. . . continued on page 26
Product Reference Guide: Willner Chemists Phyto-Tech™ Herbal Supplements
. . . continued from page 10