since 1911
• Willner Chemists •
the nutritional supplement professionals
Doctor’s Best
©2012 Doctor’s Best, Inc.
Best Fisetin featuring Cognisetin
™
offers a
naturally sourced flavonol that displays many
effects on brain cells and cognitive function
pathways in preclinical research. Normal aging
is characterized by a decline of brain motor
and cognitive functions, affecting learning,
memory, and coordination. Originally valued
chiefly for their antioxidant, radical-scavenging
activities, flavonoids are now known to have a
wide range of properties that support brain
function with age.
●
Best Fisetin featuring Cognisetin provides the
flavonol fisetin, a bioflavonoid produced in plants to
protect them from oxidative damage.
●
Cognisetin
™
is derived from the Japanese Wax
Tree, a much richer source of fisetin that has
been used for decades.
●
Fisetin can support the body’s antioxidant pool
both through direct radical scavenging activity and
through enhancement of glutathione (GSH) levels.
●
Fisetin may help to regulate production of many
proteins involved in guarding cells from oxidative
stress and in maintaining redox homeostasis (the
balance between rates of free radical production and
rates of removal by various antioxidants).
●
Researchers have also demonstrated the ability
of fisetin to enhance or maintain mitochondrial ATP
(energy) levels in nerve cells during conditions of
oxidative stress induced by the toxin iodoacetic acid.
●
Since the mitochondria are both a target for
damage by oxidants and a primary source of oxi-
dants generated inside cells, changes in mitochondr-
ial function are thought to be associated with aging;
therefore, fisetin is believed to support neurons and
aging of the brain by supporting healthy mitochon-
drial function.
●
In addition to fisetin helping to maintain GSH lev-
els while nerve cells are exposed to the toxic insults
of everyday life, fisetin has been shown in vitro to
promote detoxification aspects of the cellular defense
system against ongoing oxidative stress.
Always Ask For the Best
For more details about Best Fisetin featuring
Cognisetin, or any other Doctor’s Best science-
based product, please call us at 800-333-6977,
or visit our highly informative website at
www.drbvitamins.com.
Because you deserve it.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Willner_AutumnFlyerAug12 8/7/12 11:47 AM Page 2